Fremgangsmåde til fremstilling af farmaceutiske præparater indeholdende vecuroniumbromid

PCT No. PCT/EP94/00358 Sec. 371 Date Aug. 8, 1995 Sec. 102(e) Date Aug. 8, 1995 PCT Filed Feb. 8, 1994 PCT Pub. No. WO94/17808 PCT Pub. Date Aug. 18, 1994The invention relates to a process for preparing a pharmaceutical preparation having neuromuscular blocking activity in a vial by dissolving vecuroniumbromide or an analogue thereof in water saturated with carbondioxide or an organic solvent, filling the solution thus obtained into the vial to provide therein the required unit dosage form of vecuronium bromide or an analogue thereof, removing the solvent, i.e. water or organic solvent in the vial by lyophilization or evaporation, and hermetically closing the vial. The invention also relates to a method of preparing an aqueous injection solution starting from said vial by dissolving the contents of the vial either in an amino acid solution of sufficient concentration so as to obtain a final physiological pH or in a pharmaceutically acceptable buffer system of pH 7 to 7.4.