Antitumorpræparater og behandlingsmetoder

This invention provides certain N-phenyl-N'-substitutedphenylsulfonylureas compounds having the formula wherein: X is halo, CH3 or CF3; X is hydrogen, halo, or CF3 with the proviso that at least one of X and X is halo; A, B, D and E are (a) independently selected from group consisting of hydrogen, methyl, ethyl, chlorine, bromine and iodine with the proviso that no more than one of A, B, D or E is hydrogen, or (b) E is hydrogen and one of A, B or D is selected from the group consisting of -NH2, -NHCH3, -N(CH3)2, -N(CH3)(CH2CH3), -N(CH2CH3)2, or -OCH3 and the remaining of A, B or D are selected from (a), or (c) E is hydrogen and A and B or B and D together are -(CH2)n- or -CH=CH(CH2)n-2- wherein n is 3 or 4 or -(CH=CH)2-, or -(CH2)pO- where p is 2 or 3, or -O(CH2)qO- where q is 1 or 2 and D or A respectively is selected from (a); or pharmaceutically acceptable salt thereof, and pharmaceutical formulations employing these compounds. This invention also provides a method for treating susceptible neoplasms in mammals using these sulfonylurea compounds and processes for producing them.