Fremgangsmåder til anvendelse af 2-isopropyl-2-phenylaminovaleronitriler som immunosuppressorer og vasodilatatorer

Fremgangsmåder til anvendelse af 2-isopropyl-2-phenylaminovaleronitriler som immunosuppressorer og vasodilatatorer

Substituted 2-isopropyl-2-phenyl-5-(phenethyl amino) valeronitriles are used as immunosuppressors in a method of treatment of organ transplant rejection, either alone or concurrently with administration of cyclosporin in a synergistic manner that permits lowered dosages of cyclosporin than if cyclos...

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Bibliographische Detailangaben
Hauptverfasser: CHI-DEAN LIANG, STROM,TERRY B, MC KEARN, JOHN P, WIEDER, KENNETH J, MUELLER, RICHARD AUG
Format: Patent
Sprache:dan
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Substituted 2-isopropyl-2-phenyl-5-(phenethyl amino) valeronitriles are used as immunosuppressors in a method of treatment of organ transplant rejection, either alone or concurrently with administration of cyclosporin in a synergistic manner that permits lowered dosages of cyclosporin than if cyclosporin were to be administered alone. The mechanism of action is thought to be independent of cardiovascular calcium channel blocking activity of the compounds.