ZUSAMMENSETZUNGEN ZUR VERSTÄRKUNG DER PHARMAKOLOGISCHEN AKTIVITÄT VON IMMUNOSUPPRESSIVA

The present invention provides the compositions for efficient amplification of immunosuppressive activity of cyclosporins, FK506 or rapamycin to decrease therapeutical dose of immunosuppressants, and as the consequence to avoid their undesirable side effects during organ and tissue transplantation,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser:	KORPELA, TIMO KALEVI, ZAVIALOV, VLADIMIR PETROVICH, DOLGIKH, DMITRY ALEKSANDROVICH, KIRPICHNIKOV, MIKHAIL PETROVICH, VASILENKO, RAISA NIKOLAEVNA, NAVOLOTSKAYA, ELENA VITALIEVNA
Format:	Patent
Sprache:	ger
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention provides the compositions for efficient amplification of immunosuppressive activity of cyclosporins, FK506 or rapamycin to decrease therapeutical dose of immunosuppressants, and as the consequence to avoid their undesirable side effects during organ and tissue transplantation, and treatment of different diseases. These compositions include cyclosporins, FK506 or rapamycin and biologically active peptides corresponding to the high-affinity binding/anti-lymphoproliferative site of IFNs-a,b,w,t, or recombinant proteins having the amino acid sequences corresponding to the said site.