TETRAHYDROBEZINDOL DERIVATE

Since the compound of the present invention represented by the following formula (I) can strongly inhibit bonding of Ä HÜ-serotonin and Ä HÜ-5-CT to human serotonin 5-HT7 receptor subtype expressed in cultured cell line, the compound of formula (I) and pharmaceutically acceptable salts thereof can provide pharmaceutical conpositions for use in the treatment or prevention of mental diseases. ÄIn the above formula, A is N, CH, C having a double bond or CR ; each of B and Z is independently N, CH or CR , with the proviso that A is N when B and/or Z is N; R is a hydrogen atom, a halogen atom, a lower alkyl group, a cyano group, a trihalomethyl group, a hydroxy group, an alkoxy group, an alkylthio group, an alkylsulfinyl group, an alkylsulfonyl group, an alkoxycarbonyl group, a sulfamoyl group, an amino group, a substituted amino group, a carbamoyl group, an alkylcarbamoyl group, an acyl group or a carboxy group; R is a hydrogen atom or a lower alkyl group; R is a hydrogen atom, a lower alkyl group or an aralkyl group; R is a hydrogen atom, a halogen atom, a lower alkyl group, a hydroxy group, an alkoxy group, an acyl group, an alkoxycarbonyl group, a nitro group, an amino group, a substituted amino gropup, a carbamoyl group, an alkylcarbamoyl group or an acyloxy group; R is a lower alkyl group, a cyano group, a carbamoyl group, a carboxy group, an acyl group, an acyloxy group, an alkoxy group, an alkoxycarbonyl group, a trihalomethyl group or a hydroxy group; and n is an integer of 2 to 6.Ü