Benzothiophen-Verbindungen und Verfahren zur Anwendung

The instant invention provides novel benzothiophene compounds of formula I, wherein: R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar where Ar is phenyl or optionally substituted phenyl, -O-CO-O-Ar where Ar is phenyl or optionally substituted phenyl, or -OSO2-(C4-C...

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Bibliographische Detailangaben
Hauptverfasser:	CULLINAN, GEORGE JOSEPH, FAHEY, KENNAN JOSEPH, BRYANT, HENRY UHLMAN
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The instant invention provides novel benzothiophene compounds of formula I, wherein: R1 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar where Ar is phenyl or optionally substituted phenyl, -O-CO-O-Ar where Ar is phenyl or optionally substituted phenyl, or -OSO2-(C4-C6 alkyl); R2 is -H, -OH, -O(C1-C4 alkyl), -O-CO-(C1-C6 alkyl), -O-CO-O(C1-C6 alkyl), -O-CO-Ar where Ar is phenyl or optionally substituted phenyl, -O-CO-O-Ar where Ar is phenyl or optionally substituted phenyl, -OSO2-(C4-C6 alkyl), -F-, -Cl, or Br; A is B is -OCH2CH2NR3R4; R3 and R4 each are independently C1-C4 alkyl, or combine to form, with the nitrogen to which they are attached, piperidinyl, pyrrolidinyl, methylpyrrolidinyl, dimethylpyrrolidinyl, or hexamethyleneimino; or a pharmaceutically acceptable salt or solvate thereof for the inhibition of estrogen deprivation, postmenopausal symptoms, particularly osteoporosis, cardiovascular-related pathological conditions including hyperlipidemia and related cardiovascular pathologies, and estrogen-dependent cancer.