MINDERUNG DER TOXISCHEN EFFEKTE DES CARBOPLATINS DURCH VERWENDUNG VON DITHIOETHERN

MINDERUNG DER TOXISCHEN EFFEKTE DES CARBOPLATINS DURCH VERWENDUNG VON DITHIOETHERN

To reduce the toxic effect of carboplatin, particularly myelosuppression and emesis, a dithioether having the formula (I) R1-(CH2)n-S-S-(CH2)m-R2 wherein each of R1 and R2 individually is SO3H or PO3H2; and each of m and n is individually 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof,...

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Bibliographische Detailangaben
Hauptverfasser: HAUSHEER, HERMAN, REDDY, GAURAVARAM, MURALI, DHANABALAN, HARIDAS, KOCHAT, SEETHARAMULU, PEDDAIAHGARI
Format: Patent
Sprache:ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:To reduce the toxic effect of carboplatin, particularly myelosuppression and emesis, a dithioether having the formula (I) R1-(CH2)n-S-S-(CH2)m-R2 wherein each of R1 and R2 individually is SO3H or PO3H2; and each of m and n is individually 1, 2, 3 or 4; or a pharmaceutically acceptable salt thereof, preferably disodium 2,2'-dithiobis(ethane sulfonate) (dimesna), is administered in combination with carboplatin to a patient, at substantially the same time or sequentially, whereby the dithioether and the carboplatin become copresent in the blood of the patient. Compositions comprising carboplatin and the dithioether are included in the invention.