NEUE POLYCYCLISCHE AMINOPYRIDINE ALS ACETYLCHOLINESTERASE HEMMER, VERFAHREN ZUR HERSTELLUNG UND DEREN VERWENDUNG

New polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use. The polycyclic aminopyridine compounds correspond to the formula in which the various radicals have the meanings stated in the specification. The process for preparing these co...

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Hauptverfasser: MORRAL CARDONER, JORDI, EL ACHAB, RACHID, BADIA SANCHO, ALBERT2UNIVERSITAT DE BARCELONA, CAMPS GARCIA, PELAYO, CONTRERAS LASCORZ, JOAN, GOERBIG ROMEU DIANA MARINA, E-08028 BARCELONA, BANOS DIEZ, JOSEP ELADI, SIMON FORNELL, MONTSERRAT, VIVAS, NURIA MARIA, MUNOZ-TORRERO LOPEZ-IBARRA, DIEGO
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Sprache:ger
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Zusammenfassung:New polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use. The polycyclic aminopyridine compounds correspond to the formula in which the various radicals have the meanings stated in the specification. The process for preparing these compounds is characterized in that ketones of general formula (II) are reacted with aminonitriles of general formula (III) and, if necessary, the compounds of formula (I) are alkylated, aralkylated or acylated, or alternatively the corresponding keto precursor is reduced. The compounds of the general formula (I) are especially suitable for the preparation of medicaments against memory disorders such as senile dementia or Alzheimer's disease.