Verfahren zur Herstellung einer alpha-Hydroxy-säure oder eines alpha-Hydroxy-amids mittels Mikroorganismen

A process for producing an alpha -hydroxy acid or an alpha -hydroxyamide which comprises treating an aldehyde and prussic acid or an alpha -hydroxynitrile with a microorganism having nitrilase or nitrile hydratase activity in an aqueous medium and maintaining the aldehyde concentration and/or the al...

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Bibliographische Detailangaben
Hauptverfasser: YAMAGUCHI, YASUMASA, USHIGOME, MASAHIRO, KATO, TAKESHI
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:A process for producing an alpha -hydroxy acid or an alpha -hydroxyamide which comprises treating an aldehyde and prussic acid or an alpha -hydroxynitrile with a microorganism having nitrilase or nitrile hydratase activity in an aqueous medium and maintaining the aldehyde concentration and/or the alpha -hydroxynitrile concentration in the reaction mixture within a predetermined range. Also disclosed is a process for producing an alpha -hydroxy acid or an alpha -hydroxyamide from an aldehyde and prussic acid with a microorganism in an aqueous medium, which comprises maintaining the cyanogen concentration in the reaction mixture within a predetermined range and supplying the aldehyde to the reaction mixture at a predetermined ratio to the prussic acid.