SELEKTIVES VERFAHREN ZUR DEACYLIERUNG VON ACYLVERBINDUNGEN

The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.

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Bibliographische Detailangaben
Hauptverfasser: SIBEYN, MIEKE, DE PATER, MATTHEUS
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:The invention provides a simple and selective method for the deacylation of 4-acylated statins during the preparation of statins from a fermentation broth, more specifically a reduction of impurities from the process, by increasing the pH of the fermentation broth.