LACTONE-STABILE CAMPTOTHECIN ODER 7 - ETHYL CAMPTOTHECIN - FORMULIERUNG IN DIMETHYLISOSORBID ODER DIMETHYLACETAMID

LACTONE-STABILE CAMPTOTHECIN ODER 7 - ETHYL CAMPTOTHECIN - FORMULIERUNG IN DIMETHYLISOSORBID ODER DIMETHYLACETAMID

Camptothecin (CPT) and 7-ethyl camptothecin (ECPT), are poorly soluble in water. Because of their poor water-solubility, they have not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of tumors. The invention provides a pharmaceutical...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: HAUSHEER, HERMAN, HARIDAS, KOCHAT
Format: Patent
Sprache:ger
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Camptothecin (CPT) and 7-ethyl camptothecin (ECPT), are poorly soluble in water. Because of their poor water-solubility, they have not been directly administered by parenteral or oral routes in human patients for the purpose of inhibiting the growth of tumors. The invention provides a pharmaceutically acceptable formulation in the form of an acidic solution or suspension comprising (1) CPT or ECPT, preponderantly in the desired lactone form (1a') (wherein R is hydrogen or ethyl) and (2) dimethylisosorbide or dimethylacetamide.