Bis(hydroxymethyl)cyclopropylmethyl Pyrimidin Derivate, deren Herstellung und deren Verwendung als anti-virale Mittel

Cyclopropane derivatives of the following general formula (I) or their pharmaceutically acceptable salts, are provided, as well as anti-viral agents containing the same as the active ingredient: wherein R and R , which may be the same or different, each represents a hydrogen atom or an acyl group; R represents a halogen atom, a 2-haloalkyl group, a 2-halo-1-alkenyl group, or a 1-alkynyl group. The derivatives and their salts have anti-viral activity, for example against varicella zoster and herpes simplex, and may be used as alternatives to acyclovir. And intermediates of formulae (3) and (9) wherein R4 is a protective group for a hydroxyl group and R3 is defined as above.