SUBSTITUIERTE SPIRO-AZARINGEN ALS TACHYKININE REZEPTOR ANTAGONISTEN

PCT No. PCT/US94/00819 Sec. 371 Date Jul. 11, 1995 Sec. 102(e) Date Jul. 11, 1995 PCT Filed Jan. 25, 1994 PCT Pub. No. WO94/17045 PCT Pub. Date Aug. 4, 1994Disclosed are spiro-substituted azacycles of formula (I), are tachykinin receptor antagonists useful in the treatment of inflammatory diseases,...

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Hauptverfasser:	MACCOSS, MALCOLM, FREEHOLD, NJ 07728, US, HALE, JEFFREY, J., WESTFIELD, NJ 07090, US, QI, HONGBO, EDISON, NJ 08820, US, MILLS, SANDER, G., WOODBRIDGE, NJ 07095, US, SHAH, SHRENIK, K., METUCHEN, NJ 08840, US
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	PCT No. PCT/US94/00819 Sec. 371 Date Jul. 11, 1995 Sec. 102(e) Date Jul. 11, 1995 PCT Filed Jan. 25, 1994 PCT Pub. No. WO94/17045 PCT Pub. Date Aug. 4, 1994Disclosed are spiro-substituted azacycles of formula (I), are tachykinin receptor antagonists useful in the treatment of inflammatory diseases, pain or migraine, emesis and asthma. In particular compounds of formula (I) are shown to be neurokinin antagonists. (I)