NEUARTIGE ANTIKOAGULIERENDE PEPTIDDERIVATE UND ARZNEIMITTEL DIE SOLCHE ENTHALTEN SO WIE ENTSPRECHENDES HERSTELLUNGSVERFAHREN
PCT No. PCT/HU93/00013 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D-...
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| creator | SZEKER, GABORNE, H-1041 BUDAPEST, HU V GHELYI, BELANE, H-1021 BUDAPEST, HU JUH SZ, ATTILA, H-1139 BUDAPEST, HU MOHAI, LASZLONE, H-1173 BUDAPEST, HU BARAB S, VA, H-1025 BUDAPEST, HU SZAB, GABRIELLA, H-1132 BUDAPEST, HU HORV TH, GYULA, H-1052 BUDAPEST, HU BAJUSZ, SANDOR, H-1016 BUDAPEST, HU MORAVCSIK, IMRE, H-1095 BUDAPEST, HU P LN -ARNYOSI, KATALIN, H-1032 BUDAPEST, HU BAGDY, DANIEL, H-1222 BUDAPEST, HU L VICH, JANOSNE, H-1150 BUDAPEST, HU PALLAGI, ISTVAN, H-1157 BUDAPEST, HU FEH R, ANDRAS, H-1118 BUDAPEST, HU SZ LL, GYOERGYNE, H-1106 BUDAPEST, HU |
| description | PCT No. PCT/HU93/00013 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'-CH(OH)-CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties. |
| format | Patent |
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No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'-CH(OH)-CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties.</description><edition>6</edition><language>ger</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1999</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990211&DB=EPODOC&CC=DE&NR=69314478T2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76289</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19990211&DB=EPODOC&CC=DE&NR=69314478T2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SZEKER, GABORNE, H-1041 BUDAPEST, HU</creatorcontrib><creatorcontrib>V GHELYI, BELANE, H-1021 BUDAPEST, HU</creatorcontrib><creatorcontrib>JUH SZ, ATTILA, H-1139 BUDAPEST, HU</creatorcontrib><creatorcontrib>MOHAI, LASZLONE, H-1173 BUDAPEST, HU</creatorcontrib><creatorcontrib>BARAB S, VA, H-1025 BUDAPEST, HU</creatorcontrib><creatorcontrib>SZAB, GABRIELLA, H-1132 BUDAPEST, HU</creatorcontrib><creatorcontrib>HORV TH, GYULA, H-1052 BUDAPEST, HU</creatorcontrib><creatorcontrib>BAJUSZ, SANDOR, H-1016 BUDAPEST, HU</creatorcontrib><creatorcontrib>MORAVCSIK, IMRE, H-1095 BUDAPEST, HU</creatorcontrib><creatorcontrib>P LN -ARNYOSI, KATALIN, H-1032 BUDAPEST, HU</creatorcontrib><creatorcontrib>BAGDY, DANIEL, H-1222 BUDAPEST, HU</creatorcontrib><creatorcontrib>L VICH, JANOSNE, H-1150 BUDAPEST, HU</creatorcontrib><creatorcontrib>PALLAGI, ISTVAN, H-1157 BUDAPEST, HU</creatorcontrib><creatorcontrib>FEH R, ANDRAS, H-1118 BUDAPEST, HU</creatorcontrib><creatorcontrib>SZ LL, GYOERGYNE, H-1106 BUDAPEST, HU</creatorcontrib><title>NEUARTIGE ANTIKOAGULIERENDE PEPTIDDERIVATE UND ARZNEIMITTEL DIE SOLCHE ENTHALTEN SO WIE ENTSPRECHENDES HERSTELLUNGSVERFAHREN</title><description>PCT No. PCT/HU93/00013 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'-CH(OH)-CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1999</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjb0KwjAUhbs4iPoOF3cHrfgzBnPaXIyxJLcKLqVInEQLdfThDeIDOB34zt8wezvUyguXIOWE90dV1pbh4TSoQiWsNTyflIBqp0n5iwMfWASWNIPC0e4MCE6MsgKXAJ35C0Llkby0FMjAh1SxtSvDCb5QJl2Ms8Gtvfdx8tNRNi0gOzOL3bOJfdde4yO-Go3VNp8vl-uNyCL_K_QBhYw82Q</recordid><startdate>19990211</startdate><enddate>19990211</enddate><creator>SZEKER, GABORNE, H-1041 BUDAPEST, HU</creator><creator>V GHELYI, BELANE, H-1021 BUDAPEST, HU</creator><creator>JUH SZ, ATTILA, H-1139 BUDAPEST, HU</creator><creator>MOHAI, LASZLONE, H-1173 BUDAPEST, HU</creator><creator>BARAB S, VA, H-1025 BUDAPEST, HU</creator><creator>SZAB, GABRIELLA, H-1132 BUDAPEST, HU</creator><creator>HORV TH, GYULA, H-1052 BUDAPEST, HU</creator><creator>BAJUSZ, SANDOR, H-1016 BUDAPEST, HU</creator><creator>MORAVCSIK, IMRE, H-1095 BUDAPEST, HU</creator><creator>P LN -ARNYOSI, KATALIN, H-1032 BUDAPEST, HU</creator><creator>BAGDY, DANIEL, H-1222 BUDAPEST, HU</creator><creator>L VICH, JANOSNE, H-1150 BUDAPEST, HU</creator><creator>PALLAGI, ISTVAN, H-1157 BUDAPEST, HU</creator><creator>FEH R, ANDRAS, H-1118 BUDAPEST, HU</creator><creator>SZ LL, GYOERGYNE, H-1106 BUDAPEST, HU</creator><scope>EVB</scope></search><sort><creationdate>19990211</creationdate><title>NEUARTIGE ANTIKOAGULIERENDE PEPTIDDERIVATE UND ARZNEIMITTEL DIE SOLCHE ENTHALTEN SO WIE ENTSPRECHENDES HERSTELLUNGSVERFAHREN</title><author>SZEKER, GABORNE, H-1041 BUDAPEST, HU ; 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No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'-CH(OH)-CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NEUARTIGE ANTIKOAGULIERENDE PEPTIDDERIVATE UND ARZNEIMITTEL DIE SOLCHE ENTHALTEN SO WIE ENTSPRECHENDES HERSTELLUNGSVERFAHREN |
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