NEUARTIGE ANTIKOAGULIERENDE PEPTIDDERIVATE UND ARZNEIMITTEL DIE SOLCHE ENTHALTEN SO WIE ENTSPRECHENDES HERSTELLUNGSVERFAHREN

NEUARTIGE ANTIKOAGULIERENDE PEPTIDDERIVATE UND ARZNEIMITTEL DIE SOLCHE ENTHALTEN SO WIE ENTSPRECHENDES HERSTELLUNGSVERFAHREN

PCT No. PCT/HU93/00013 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D-...

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Hauptverfasser: SZEKER, GABORNE, H-1041 BUDAPEST, HU, V GHELYI, BELANE, H-1021 BUDAPEST, HU, JUH SZ, ATTILA, H-1139 BUDAPEST, HU, MOHAI, LASZLONE, H-1173 BUDAPEST, HU, BARAB S, VA, H-1025 BUDAPEST, HU, SZAB, GABRIELLA, H-1132 BUDAPEST, HU, HORV TH, GYULA, H-1052 BUDAPEST, HU, BAJUSZ, SANDOR, H-1016 BUDAPEST, HU, MORAVCSIK, IMRE, H-1095 BUDAPEST, HU, P LN -ARNYOSI, KATALIN, H-1032 BUDAPEST, HU, BAGDY, DANIEL, H-1222 BUDAPEST, HU, L VICH, JANOSNE, H-1150 BUDAPEST, HU, PALLAGI, ISTVAN, H-1157 BUDAPEST, HU, FEH R, ANDRAS, H-1118 BUDAPEST, HU, SZ LL, GYOERGYNE, H-1106 BUDAPEST, HU
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:PCT No. PCT/HU93/00013 Sec. 371 Date Dec. 5, 1994 Sec. 102(e) Date Dec. 5, 1994 PCT Filed Mar. 4, 1993 PCT Pub. No. WO93/18060 PCT Pub. Date Sep. 16, 1993This invention relates to new peptide derivatives of the general formula (I) A-Xaa-Arg-H, wherein A represents a D- or L-isochroman-1-carbonyl, D- or L-isochroman-3-carbonyl group, furthermore an acyl group of the general formula: D- or DL-A'-CH(OH)-CO, wherein A' represents a phenyl, benzyl, 1-naphthyl, 1-naphthylmethyl, 2-naphthyl, 2-naphthylmethyl, 9-fluorenyl, benzhydryl, cyclohexyl, cyclohexylmethyl, 2-pyridyl, 3-pyridyl or 4-pyridyl group, and Xaa represents an L-prolyl or an L-pipecolinic acid residue, and Arg stands for an L-arginine residue, their acid addition salts formed with an organic or inorganic acid and pharmaceutical compositions containing the same. Furthermore the invention relates to a process for preparing them. The compounds of the invention have valuable therapeutic, particularly anticoagulant, properties.