Substituierte Benzoate-Derivate

The present invention relates to the compounds of the formula: in which R , R , R , R , R , R , R , and R are independently hydrogen, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, hydroxy, acyloxy, or halogen; R is hydrogen, hydroxy, acyloxy, lower alkyl...

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Hauptverfasser: TANAKA, KAZUSHIGE, NISHINOMIYA-SHI, HYOGO-KEN, JP, YOSHIDA, TADASHI, TOYONO-GUN, OSAKA-FU, JP, FUJII, YASUHIKO, KOBE-SHI, HYOGO-KEN, JP, SAKAZAKI, RYUJI, KITAKATSURAGI-GUN, NARA-KEN, JP, MATSUTANI, SHIGERU, HASHIMOTO-SHI, WAKAYAMA-KEN, JP
Format: Patent
Sprache:ger
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Zusammenfassung:The present invention relates to the compounds of the formula: in which R , R , R , R , R , R , R , and R are independently hydrogen, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, hydroxy, acyloxy, or halogen; R is hydrogen, hydroxy, acyloxy, lower alkyl which is optionally substituted, lower alkoxy which is optionally substituted, or lower alkylamino which is optionally substituted; E is hydrogen, or an ester residue; m is an integer of from 1 to 4; or a pharmaceutically acceptable salt thereof. The compounds of the present invention exhibit phospholipase A2 inhibitory activity, and can be used in treating inflammatory conditions.