Spicamycinderivate und deren Verwendung

Disclosed is a novel spicamycin derivative represented by the formula (I) or a salt thereof: wherein R represents an alkenyl having a given number of carbon atoms, a haloalkyl having a given number of carbon atoms, CH3(CH2)nCH(OH)- or CH3(CH2)n-lCH(OH)-CH2- (wherein n denotes an integer of 9-13), an...

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Bibliographische Detailangaben
Hauptverfasser:	OTAKE, NOBORU, TOSHIMA-KU, TOKYO-TO, JP, KAWASAKI, TOMIKO, ODAGAWA, ATSUO, KAWAI, HIROYUKI, SAKAI, TERUYUKI, KAMISHOHARA, MASARU
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY DERIVATIVES THEREOF ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Disclosed is a novel spicamycin derivative represented by the formula (I) or a salt thereof: wherein R represents an alkenyl having a given number of carbon atoms, a haloalkyl having a given number of carbon atoms, CH3(CH2)nCH(OH)- or CH3(CH2)n-lCH(OH)-CH2- (wherein n denotes an integer of 9-13), an alkyl with a certain group and a given number of carbon atoms, (wherein a denotes 2, and b denotes an integer of 10-15), CH3(CH2)cSO2O(CH2)d- , (wherein c denotes an integer of 0-3 and d denotes an integer of 10-15), (CH3)3Si(CH2)10- , (CH3)3Si-C IDENTICAL C-(CH2)8-, or (wherein X represents O or S), and R1 and R2 are different from each other and each represents H or OH, which exhibits an excellent antitumor effect and has a high therapeutic index. An antitumor agent containing at least one of the above-described compounds in an effective amount is also disclosed.