Verabreichungsverfahren von Dipalmitoylphosphatidylcholindispersionen

A method of administering a surfactant dispersion to the lungs of a patient in need of such treatment is disclosed. The method comprises heating the dispersion and nebulizing the heated dispersion to produce respirable surfactant particles. The respirable surfactant particles delivered to the lungs...

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Bibliographische Detailangaben
Hauptverfasser:	SNYDER, RODNEY GARY, GREENVILLE, NC 27858, US, DAVIS, CRAIG WILLIAM, GREENVILLE, PITT COUNTY, NC 27858, US
Format:	Patent
Sprache:	ger
Schlagworte:	DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROMTHE BODY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	A method of administering a surfactant dispersion to the lungs of a patient in need of such treatment is disclosed. The method comprises heating the dispersion and nebulizing the heated dispersion to produce respirable surfactant particles. The respirable surfactant particles delivered to the lungs of the patient. By heating the dispersion the amount of phospholipid delivered to the lungs of the patient is increased. The dispersion is comprised of a phospholipid dispersed in an aqueous carrier. In a particular embodiment of the invention, the phospholipid is preferably dipalmitoylphosphatidylcholine (DPPC) included in an amount from about 8 to 50 milligrams per milliliter of aqueous carrier, and the dispersion is preferably heated to a temperature between about 25 DEG C and 75 DEG C.