BIOLOGISCH AKTIVE AMINE

There are disclosed compounds of the formula (I): Ar-CH2CH2-NH-CR R -X-Y in which Ar represents a group alpha , X represents a C1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from -S-, -SO-, -SO2-, -O-, CR R , phenylmethyne, -NH-, -CONH-, -NHCO- and -NHCONH-,...

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Bibliographische Detailangaben
Hauptverfasser: DIXON, JOHN, CHESHIRE, DAVID RAYULS, BONNERT, ROGER VICTOR, BROWN, ROGER CHARLES, INCE, FRANCIS
Format: Patent
Sprache:ger
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Zusammenfassung:There are disclosed compounds of the formula (I): Ar-CH2CH2-NH-CR R -X-Y in which Ar represents a group alpha , X represents a C1-12 alkylene chain optionally interrupted or terminated by one or more groups selected from -S-, -SO-, -SO2-, -O-, CR R , phenylmethyne, -NH-, -CONH-, -NHCO- and -NHCONH-, Y represents an optionally substituted aryl or cycloalkyl group, R , R , R , R , R and R each independently represent hydrogen or alkyl C1-6, and R and R represent hydrogen, or R and R together form a group -S-, -NR - or -CH2-, and pharmaceutically acceptable derivatives thereof. Processes for their production and pharmaceutical compositions and methods of treatment involving their use are also described.