NICHTWÄSSRIGE POLYMERE REAGENZZUSAMMENSETZUNGEN UND DEREN ANWENDUNGEN

Non-aqueous, polymeric reagent film compositions for use with analytical test devices of the dry chemistry type are described. The film compositions are prepared from an organic solution of a copolymer formed by interaction of at least two monomers wherein (a) the first monomer is a hydroxylated acr...

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Hauptverfasser: DIEBOLD, ERIC R, FISHERS, INDIANA 46038, US, SKARSTEDT, MARK, T., PENDLETON, IN 46064, US, RAPKIN, MYRON C., INDIANAPOLIS, INDIANA 46220, US, BURKE, ANTHONY, B., INDIANAPOLIS, IN 46218, US, USMANI, ARTHUR, M., INDIANAPOLIS, IN 46278, US, DUBOIS, JILL, INDIANAPOLIS, IN 46250, US, AZHAR, ABOL, F., FISHERS, IN 46038, US
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Sprache:ger
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Zusammenfassung:Non-aqueous, polymeric reagent film compositions for use with analytical test devices of the dry chemistry type are described. The film compositions are prepared from an organic solution of a copolymer formed by interaction of at least two monomers wherein (a) the first monomer is a hydroxylated acrylate of the general formula where R1 is hydrogen or, more preferably, methyl, and R2 is a hydroxyalkyl group having from 1 to 5 carbon atoms, and (b) the second monomer is a neutral acrylate of the general formula where R1 is hydrogen or, more preferably, methyl, and R3 is a substituted or unsubstituted alkyl group having from 1 to 8 carbon atoms. Preferably, a third monomer is also included which is an amine-containing acrylate of the general formula where R1 is hydrogen or, more preferably, methyl, and R4 is a substituted or unsubstituted aminoalkyl or glycidyl group having from 1 to 5 carbon atoms or a surfactant polyethylene glycol group having from 10 to 30 carbon atoms. The film further comprises at least one enzyme in powder form dispersed therein and, optionally, a chromogenic indicator. The film composition is especially useful for determining components in body fluids, for example, for detecting glucose in whole blood, by rapid techniques.