EINSCHLUSSKOMPLEXE DES 3-MORPHOLINO-SYDNONIMINS ODER SEINE SALZE ODER SEINE ISOMEREN TAUTOMERE, VERFAHREN ZUR HERSTELLUNG DIESER KOMPLEXE UND PHARMAZEUTISCHE ZUSAMMENSETZUNGEN DIE DIESE KOMPLEXE ENTHALTEN

PCT No. PCT/HU91/00013 Sec. 371 Date Jan. 2, 1992 Sec. 102(e) Date Jan. 2, 1992 PCT Filed Mar. 28, 1991.The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the sam...

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Hauptverfasser: VIKMON, MARIA, H-1026 BUDAPEST, HU, SZEJTLI, JOZSEF, H-1026 BUDAPEST, HU, HERMECZ, ISTVAN, H-1056 BUDAPEST, HU, GAAL, JOZSEF, H-1174 BUDAPEST, HU, MARMAROSI, KATALIN, H-2051 BIATORBAGY, HU, MUNKACSI, IREN, H-1084 BUDAPEST, HU, HORVATH, AGNES, H-1021 BUDAPEST, HU, HORVATH, GABOR, H-1133 BUDAPEST, HU, SZENTE, LAJOS, H-1033 BUDAPEST, HU
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Zusammenfassung:PCT No. PCT/HU91/00013 Sec. 371 Date Jan. 2, 1992 Sec. 102(e) Date Jan. 2, 1992 PCT Filed Mar. 28, 1991.The invention relates to inclusion complexes of 3-morpholino-sydnonimine or its salts or its tautomer isomer, process for the preparation thereof and pharmaceutical compositions containing the same. The inclusion complex of 3-morpholino-sydnonimine or its salt formed with cyclodextrin derivative is prepared by a) reacting the 3-morpholino-sydnonimine or its salt in an aqueous medium with a cyclodextrin derivative and the complex is isolated from the solution by dehydratation, or b) high energy milling of 3-morpholino-sydnonimine or its salt and a cyclodextrin derivative.