Verfahren zur Beeinflussung der Produktion von beta-lactam Antibiotika und zur Isolierung grosser Mengen von ACV-Synthetase

Novel methods and compositions are provided for the enhanced production of fermentable or known and new beta -lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P.chrysogenum and A.chrysogenum delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetas...

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Hauptverfasser:	MARTIN, JUAN FRANCISCO, E-24004 LEON, ES, GARCIA, BRUNO DIEZ, SAN SEBASTIAN (GUIPUZCOA), ES, VAN LIEMPT, HENK, W-1000 BERLIN 61, DE, VEENSTRA, ANNEMARIE EVELINE, NL-2151 XH NIEUW VENNEP, NL, VON DOEHREN, HANS, W-1000 BERLIN 12, DE, GUTTIEREZ, SANTIAGO, LEON, ES, BARREDO, JOSE LUIS, BURGOS, ES, PALISSA, HARRIET, W-1000 BERLIN 61, DE, MONTENEGRO PRIETO, EDUARDO, E-24002 LEON, ES
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Novel methods and compositions are provided for the enhanced production of fermentable or known and new beta -lactam antibiotics. The process is exemplified by the production of penicillin. In addition, the P.chrysogenum and A.chrysogenum delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase genes have been isolated and sequenced. Also methods are provided for the production of delta -(L- alpha -aminoadipyl)-L-cysteinyl-D-valine synthetase using recombined DNA techniques.