GENETISCHER TEST FÜR ZYTOCHROM-P450

Polymorphisms at positions 100, 271, 281, 294, 408, 506 or 1432 of the cytochrome P450 enzyme bufuralol-1'-hydroxylase are indicative of the extensive metaboliser/poor metaboliser phenotypes and can be detected using known methods such as amplification of the DNA with the polymerase chain react...

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Hauptverfasser:	WOLF, CHARLES ROLAND IMPERIAL CANCER RESEARCH FUND, GEORGE SQUARE EDINBURGH EH8 9XD, GB, MILES, JOHN, STEPHEN DEPARTMENT OF BIOISTRY, GLASGOW G12 8QQ, GB, GOUGH, ALAN, CHARLES IMPERIAL CANCER RESEARCH FUND, SOUTH MIMMS, POTTERS BAR HERTS EN6 3LD, GB, SPURR, NIGEL, KAY IMPERIAL CANCER RESEARCHFUND, SOUTH MIMMS, POTTERS BAR HERTS EN6 3LD, GB
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Polymorphisms at positions 100, 271, 281, 294, 408, 506 or 1432 of the cytochrome P450 enzyme bufuralol-1'-hydroxylase are indicative of the extensive metaboliser/poor metaboliser phenotypes and can be detected using known methods such as amplification of the DNA with the polymerase chain reaction, followed by digestion with a suitable restriction enzyme and analysis by gel electrophoresis. The EM/PM phenotype is relevant to calculating safe or effective drug doses for individuals.