Hochreine kristalline Formen der Peptide Arg-Lys-Asp und Arg-Lys-Asp-Val, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

Hochreine kristalline Formen der Peptide Arg-Lys-Asp und Arg-Lys-Asp-Val, Verfahren zu ihrer Herstellung und sie enthaltende pharmazeutische Zusammensetzungen

The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys...

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Hauptverfasser: SZPORNY, LASZLO., H-1114 BUDAPEST, HU, PETER, IMRE, H-1111 BUDAPEST, HU, DENES, LASZLO,DR., H-1173 BUDAPEST, HU, KOVACS, LAJOS, H-1196 BUDAPEST, HU, SCHON, ISTVAN DR., H-1142 BUDAPEST, HU, HAJOS, GYOE-RGY., H-1026 BUDAPEST, HU, UBERHARDT, ILDIKO NEE FALUDI, H-1181 BUDAPEST, HU, UBERHARDT, TAMAS, H-1181 BUDAPEST, HU, MUCK, ZSUZSANNA NEE KEREPESI, H-1165 BUDAPEST, HU, LORANT, GIZELLA NEE MAREK, H-2200 MONOR, HU, IVANYI, GEZA, H-2335 TAKSONY, HU, GAZDAG, MARIA DR., H-1112 BUDAPEST, HU, NYEKI, OLGA, H-1151 BUDAPEST, HU
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The present invention relates to a process for the preparation of high purity crystalline forms of peptides Arg-Lys-Asp and Arg-Lys-Asp-Val from crude, amorphous peptides Arg-Lys-Asp and Arg-Lys-Asp-Val. The process is characterized in that the crude, amorphous peptide Arg-Lys-Asp or peptide Arg-Lys-Asp-Val is allowed to stand at room temperature with 5 to 20 unit volume of an ethanolic solution containing 0.5 to 4.0% by volume of acetic acid and 5 to 25% by volume of water, wherein the volume unit is calculated for the mass unit of the material and mass unit relates to volume unit as g relates to ml, then the crystallized peptide is separated from the crystalline suspension, preferably after cooling. Pharmaceutical compositions containing the crystalline forms of these peptides are also described.