Weitere antivirale Pyrimidin-Nukleosiden

Pyrimidine 4 min -thionucleosides of the formula (I) where B is a pyrimidine base; and either (a) R is hydrogen and R is hydroxy or fluoro, or (b) R is hydroxy and R is hydrogen, hydroxy or fluoro, or (c) R is fluoro and R is hydrogen or hydroxy, or (d) R and R together form a carbon-carbon bond; an...

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Bibliographische Detailangaben
Hauptverfasser:	COE, PAUL, DEPARTMENT OF ISTRY, BIRMINGHAM B15 2TT, GB, RAHIM, SAAD GEORGE, DEPARTMENT OF MEDICINAL ., LANGLEY COURT, BECKENHAM, KENT BR6 0TZ, GB, WALKER, RICHARD, DEPARTMENT OF ISTRY, BIRMINGHAM B15 2TT, GB
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS
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Beschreibung
Zusammenfassung:	Pyrimidine 4 min -thionucleosides of the formula (I) where B is a pyrimidine base; and either (a) R is hydrogen and R is hydroxy or fluoro, or (b) R is hydroxy and R is hydrogen, hydroxy or fluoro, or (c) R is fluoro and R is hydrogen or hydroxy, or (d) R and R together form a carbon-carbon bond; and physiologically functional derivatives thereof and processes for their production. Preferably, the base B is of the formula (II) wherein Y is hydroxy or amino, monoalkylamino or dialkylamino; and X is halogen, alkoxy, alkyl, haloalkyl, alkenyl, haloalkenyl, alkynyl, amino, monoalkylamino, dialkylamino, cyano or nitro. The compounds are useful in the treatment of viral infections.