HERSTELLUNG EINES VIRUS UND REINIGUNG VON VIRENÜBERZUGSPROTEINEN ZUR IMPFSTOFFVERWENDUNG

Immunogenic envelope glycoproteins are produced from enveloped virus, such as of the paramyxoviridae family, particularly PIV-3 and RSV, by culturing the virus in the substantial absence of exogenous serum proteins, isolating the virus from the tissue culture, solubilizing the envelope glycoproteins...

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Hauptverfasser: BONNEAU, ANNE-MARIE, TORONTO, ON, M4A 2T3, CA, CAPLAN, BARRY IAN, THORNHILL, ON, L4J 6J2, CA, KLEIN, MICHEL HENRI, WILLOWDALE, ON, M5A 3M2, CA, EWASYSHYN, MARY ELIZABETH, WILLOWDALE, ON, M2R 3N7, CA
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Sprache:ger
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Zusammenfassung:Immunogenic envelope glycoproteins are produced from enveloped virus, such as of the paramyxoviridae family, particularly PIV-3 and RSV, by culturing the virus in the substantial absence of exogenous serum proteins, isolating the virus from the tissue culture, solubilizing the envelope glycoproteins and isolating the solubilized envelope glycoproteins by chromatography.