Nicotinsäurederivate und diese enthaltende pharmazeutische Zusammensetzungen

Nicotinsäurederivate und diese enthaltende pharmazeutische Zusammensetzungen

Compounds are disclosed of the formula wherein R1 is hydrogen or C1-C6 alkyl; Y is -CH2-, -O-, R2 is C1-C6 alkyl; C2-C6 alkenyl; C3-C6 cycloalkyl; phenyl which may be mono- or di-substituted on the phenyl ring with C1-C6 alkoxy; aralkyl which may be mono- or di-substituted on the aromatic ring with...

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Bibliographische Detailangaben
Hauptverfasser: MIURA, KATSUTOSHI, IRUMA-GUN, SAITAMA-KEN, JP, YAMADA, HIROAKI, KAWAGOE-SHI, SAITAMA-KEN, JP, SUGAI, TOSHIJI, IRUMA-GUN, SAITAMA-KEN, JP, KOYAMA, HIROYASU, AGEO-SHI, SAITAMA-KEN, JP, SAKURAI, EINOSUKE, IRUMA-GUN, SAITAMA-KEN, JP
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Compounds are disclosed of the formula wherein R1 is hydrogen or C1-C6 alkyl; Y is -CH2-, -O-, R2 is C1-C6 alkyl; C2-C6 alkenyl; C3-C6 cycloalkyl; phenyl which may be mono- or di-substituted on the phenyl ring with C1-C6 alkoxy; aralkyl which may be mono- or di-substituted on the aromatic ring with C1-C6 alkoxy; diphenylmethyl; carboalkoxy; or an O- or N-heterocyclic radical which is linked to the nitrogen atom via carbonyl or carbonylmethylene; m is 2 or 3; and n is 0 or 1, and physiologically acceptable acid addition salts thereof. The compounds of formula (I) are of a blood flow-increasing action and can be used for the therapy or prevention of diseases in the cardiovascular system.