Acryloylsubstituierte Pyrrol-Derivate

Acryloylsubstituierte Pyrrol-Derivate

The invention relates to acryloyl substituted pyrrole derivatives of formula (I) wherein n is an integer of 1 to 5; each of R1 and R2, which may be the same or different, is hydrogen, halogen, -CN, -NO2, C1-C4 alkyl, or a group R3 is hydrogen, halogen, -CN, or -NO2; each R4 is, independently, hydrog...

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Hauptverfasser: PEZZONI, GABRIELLA, I-20127 MILANO, IT, BIASOLI, GIOVANNI, I-21026 GAVIRATE (VA), IT, MONGELLI, NICOLA, I-20137 MILANO, IT, CAPOLONGO, LAURA, I-20146 MILANO, IT
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The invention relates to acryloyl substituted pyrrole derivatives of formula (I) wherein n is an integer of 1 to 5; each of R1 and R2, which may be the same or different, is hydrogen, halogen, -CN, -NO2, C1-C4 alkyl, or a group R3 is hydrogen, halogen, -CN, or -NO2; each R4 is, independently, hydrogen or C1-C4 alkyl; A is a bond, a group or a group -NH-Het-CO-, wherein Het is a saturated or unsaturated pentatomic or hexatomic heteromonocyclic ring; and B is a group in which m is 1, 2 or 3 and each R5 is, independently, a C1-C4 alkyl group, and pharmaceutically acceptable salts thereof, which are useful as antineoplastic agents.