METHODEN ZUR VERWENDUNG VON 2-ISOPROPYL-2-PHENYLAMINOVALERIANSAEURENITRILEN ALS IMMUNOSUPRESSOREN UND VASODILATOREN

METHODEN ZUR VERWENDUNG VON 2-ISOPROPYL-2-PHENYLAMINOVALERIANSAEURENITRILEN ALS IMMUNOSUPRESSOREN UND VASODILATOREN

Substituted 2-isopropyl-2-phenyl-5-(phenethyl amino) valeronitriles are used as immunosuppressors in a method of treatment of organ transplant rejection, either alone or concurrently with administration of cyclosporin in a synergistic manner that permits lowered dosages of cyclosporin than if cyclos...

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Hauptverfasser: WIEDER, KENNETH J., DEDHAM, MASSACHUSETTS 02026, US, CHI-DEAN LIANG, CHI-DEAN LIANG, GLENVIEW ILLINOIS 60025, US, MUELLER, RICHARD AUGUST, GLENCOE, ILL. 60022, US, STROM, TERRY B., BROOKLINE, MASSACHUSETTS 02146, US, MC KEARN, JOHN P., PACIFIC, MISSOURI 63069, US
Format: Patent
Sprache:ger
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Substituted 2-isopropyl-2-phenyl-5-(phenethyl amino) valeronitriles are used as immunosuppressors in a method of treatment of organ transplant rejection, either alone or concurrently with administration of cyclosporin in a synergistic manner that permits lowered dosages of cyclosporin than if cyclosporin were to be administered alone. The mechanism of action is thought to be independent of cardiovascular calcium channel blocking activity of the compounds.