VERFAHREN ZUR REKOMBINATION IN VIVO VON TEILWEISE HOMOLOGEN DNS-SEQUENZEN

The present invention relates to a process of recombination in vivo of partially homologous DNA sequences having up to 30% of base mismatches. According to its essential characteristic, said sequences are placed together in cells or an organism of which the enzymatic mismatch repair system is defect...

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Bibliographische Detailangaben
Hauptverfasser: RADMAN, MIROSLAV, CNRS, 75007 PARIS, FR, RAYSSIGUIER, CHRISTIANE, F-91940 LES ULIS, FR
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:The present invention relates to a process of recombination in vivo of partially homologous DNA sequences having up to 30% of base mismatches. According to its essential characteristic, said sequences are placed together in cells or an organism of which the enzymatic mismatch repair system is defective or has been transitorily inactivated by saturation for the time to obtain recombination between said DNA sequences or in using mutants which increase the intergeneric recombination.