Verbindungen von Pyrimidin 2'-Methylidin Nukleosiden

Pyrimidine 2 min -deoxy-2 min -methylidene nucleoside compounds : wherein R represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R and R represent the same or different hydrogen, silyl, ac...

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Hauptverfasser: SASAKI, TAKUMA, KANAZAWA-SHI ISHIKAWA 921, JP, MIYASHITA, TAKANORI, CHOSHI-SHI CHIBA 288, JP, UEDA, TOHRU, SAPPORO-SHI HOKKAIDO 064, JP, YAMAGAMI, KEIJI, BALTIMORE, MD 21224, US, FUJII, AKIHIRO, KIYOSE-SHI TOKYO 204, JP, SAKATA, SHINJI, CHOSHI-SHI CHIBA 288, JP, MATSUDA, AKIRA MINAMISHINKAWA-KOMUINSHUKUSHA10-501, SAPPORO-SHI HOKKAIDO 001, JP
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Sprache:ger
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Zusammenfassung:Pyrimidine 2 min -deoxy-2 min -methylidene nucleoside compounds : wherein R represents amino, hydroxy, silylamino, silyloxy, acylamino or acyloxy; R represents hydrogen, halogen, a lower alkyl, a lower alkenyl, a lower alkynyl or haloalkyl; R and R represent the same or different hydrogen, silyl, acyl or aminoacyl, or a pharmaceutically acceptable salt or hydrate thereof, except that R is amino or hydroxy, and both of R and R are hydrogen. Said compounds possess excellent antitumor and antiviral activities, thus providing novel anticancer and antiviral agent.