Cycloalkanderivate

The invention concerns a cycloalkane derivative of the formula I, wherein Ar is optionally substituted phenyl or naphthyl; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene; Ar is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to th...

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Bibliographische Detailangaben
1. Verfasser: GIRODEAU, JEAN-MARC MARIE MAURICE, F-51500 RILLY LA MONTAGUE, FR
Format: Patent
Sprache:ger
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Beschreibung
Zusammenfassung:The invention concerns a cycloalkane derivative of the formula I, wherein Ar is optionally substituted phenyl or naphthyl; A is (1-6C)alkylene, (3-6C)alkenylene, (3-6C)alkynylene or cyclo-(3-6C)alkylene; Ar is optionally substituted phenylene, or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; R is hydrogen, (1-6C)alkyl, (3-6C)alkenyl, (3-6C)alkynyl, cyano-(1-4C)alkyl or (2-4C)alkanoyl, or optionally substituted benzoyl; and R and R together form a (3-6C)alkylene group which defines an optionally substituted ring having 4 to 7 ring atoms; or a pharmaceutically-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.