In 2-Stellung substituierte Cumaranderivate

The present invention relates to a compound of the formula: wherein R is hydrogen or a lower alkyl; R is methyl which is substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group or C2-15 chain-like hydrocarbon residue having no lower alkyl at the a-position which may be substituted by a carboxy, alkoxycarbonyl, cyano, halogen, aryl or heterocyclic group; R is a lower alkyl; R is hydrogen or acyl; and R and R each is a lower alkyl or lower alkoxy, or R and R combinedly are butadienylene or a salt thereof. The compound (I) of the present invention has a strong 5- and 12-lipoxygenase inhibiting action, is of high safety and is useful as, among others, an agent for ameliorating circulatory system, an anti-allergic agent and a pharmaceutical agent for central nervous system