In 2-Stellung substituierte Cumaranderivate

The present invention relates to a compound of the formula: wherein R stands for hydrogen or a lower alkyl; n denotes an integer of 1 to 6; X stands for an optionally oxidized sulphur atom, oxygen atom or an optionally substituted imino; R stands for methyl or an organic residual group bonded through methylene, methine a quaternary carbon; R stands for a lower alkyl; R stands for hydrogen or acyl; R and R each stand for a lower alkoxy or a lower alkyl, or R and R combinedly stand for butadienylene, and salts thereof. The compound (I) of the present invention has a strong 5-lipoxygenase inhibiting action, is of high safety and is useful as, among others, an agent for ameliorating circulatory system, an anti-allergic agent and a pharmaceutical agent for central nervous system.