VERFAHREN ZUR HERSTELLUNG VON 4-AMINO-1-HYDROXYBUTYLIDEN-1,1-BISPHOSPHONSÄURE

This invention is related with the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof. The reaction of 4-aminobutyric acid with phosphorous acid and phosphorus trichloride in the presence of aralkyl or alkyl ethoxylates or triglycerides such as plant or animal oils or...

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Bibliographische Detailangaben
Hauptverfasser: ASLAN, TUNCER, SAHBAZ, FILIZ, DABAK, KADIR, OZARSLAN, EVREN
Format: Patent
Sprache:ger
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Zusammenfassung:This invention is related with the preparation of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof. The reaction of 4-aminobutyric acid with phosphorous acid and phosphorus trichloride in the presence of aralkyl or alkyl ethoxylates or triglycerides such as plant or animal oils or their derivatives; and recovering of 4-amino-1-hydroxybutylidene-1,1-biphosphonic acid or salts thereof are described. The main feature of the invention is in the use of the above defined non-ionic emulgators in the phosphonylation reaction.