HYDROXAMATSULFONAMIDE ALS INHIBITOREN VON CD23-SHEDDING

A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent i...

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Hauptverfasser: OWEN, DAVID ALAN, SHARPE, ANDREW, ALLEN, DANIEL REES, DYKE, HAZEL JOAN, WATSON, ROBERT JOHN
Format: Patent
Sprache:ger
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Zusammenfassung:A class of piperidine and related heterocyclic derivatives, C-substituted by a substituted aryl or heteroaryl moiety, and N-substituted by an ethylsulfonyl group which in turn is substituted at the 2-position by a hydroxamic acid moiety and also by a range of alternative substituents, being potent inhibitors of CD23 shedding, are useful in the treatment and/or prevention of allergic, inflammatory and neoplastic diseases.