PARTIKEL ZUR INHALATION: Herstellungsmethode

A method for preparing particles suitable for pulmonary drug delivery by inhalation, and inhalation compositions comprising such particles are provided. The method comprises providing a liquid feed stock comprising one or several active agents, atomising the liquid feed stock, suspending the droplet...

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Bibliographische Detailangaben
Hauptverfasser:	AHONEN, Petri, MUTTONEN, Esa, WATANABE, Wiwik, BROWN, David, JÄRVINEN, Raoul, KAUPPINEN, Esko, JOKINIEMI, Jorma
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES DISINFECTION, STERILISATION, OR DEODORISATION OF AIR HUMAN NECESSITIES HYGIENE MAKING GRANULES OR PREFORMS MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL PERFORMING OPERATIONS PREPARATION OR PRETREATMENT OF THE MATERIAL TO BESHAPED PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES RECOVERY OF PLASTICS OR OTHER CONSTITUENTS OF WASTE MATERIALCONTAINING PLASTICS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS TRANSPORTING WORKING OF PLASTICS WORKING OF SUBSTANCES IN A PLASTIC STATE, IN GENERAL
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Beschreibung
Zusammenfassung:	A method for preparing particles suitable for pulmonary drug delivery by inhalation, and inhalation compositions comprising such particles are provided. The method comprises providing a liquid feed stock comprising one or several active agents, atomising the liquid feed stock, suspending the droplets in a carrier gas, and passing the carrier gas and droplets through a heated tube flow reactor under predetermined residence time and temperature history, and collecting the particles produced. Fine uniform crystalline spherical uncharged particles with narrow aerodynamic particle size distribution between about 1 to 5 mum and rough surfaces, are obtained. The particles show improved dispersibility and stability.