VERFAHREN ZUR HERSTELLUNG VON BIOZYKLISCHEN VERBINDUNGEN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON ICE INHIBITOREN

VERFAHREN ZUR HERSTELLUNG VON BIOZYKLISCHEN VERBINDUNGEN UND DEREN VERWENDUNG ZUR HERSTELLUNG VON ICE INHIBITOREN

A method for preparing compounds of formula (I)wherein R is selected from the group consisting of H. alkyl, aryl, and aralkyl of up to 18 carbon atoms and the amine function may be free or protected from a compound of formula (IA) wherein cyclization is carried out in a basic medium and in the prese...

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Bibliographische Detailangaben
Hauptverfasser: CROCQ, VERONIQUE, ROUSSEL, PATRICK
Format: Patent
Sprache:ger
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:A method for preparing compounds of formula (I)wherein R is selected from the group consisting of H. alkyl, aryl, and aralkyl of up to 18 carbon atoms and the amine function may be free or protected from a compound of formula (IA) wherein cyclization is carried out in a basic medium and in the presence of a phosphonic acid derivative and the use of said method as an intermediate step for preparing a compound inhibiting the interleukin-1 beta conversion enzyme.