Prepn. of vaccine against allergy inducing cpds

Prepn. of vaccine against allergy inducing cpds

Prepn. of human vaccine against substances (A), which induce allergies, comprises: (a) sepg. the relevant IgE from blood of allergy patients by known methods such as ammonium sulphate pptn. and/or chromatography, including affinity chromatography; (b) treating the isolated IgE with a mixt. of alumin...

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Bibliographische Detailangaben
1. Verfasser: BRILLINGER, GERT-ULF., 72658 BEMPFLINGEN, DE
Format: Patent
Sprache:eng ; ger
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:Prepn. of human vaccine against substances (A), which induce allergies, comprises: (a) sepg. the relevant IgE from blood of allergy patients by known methods such as ammonium sulphate pptn. and/or chromatography, including affinity chromatography; (b) treating the isolated IgE with a mixt. of aluminium hydroxides, silica and phenol and (c) incubating the IgE overnight at room temp. The antibody modified by deposition on the colloidal substances is then reinjected into patients with the corresp. allergy. Also claimed is a modification of above mentioned method, where the isolated IgE is converted to F(ab)2 or Fc fragments by acid or enzymatic hydrolysis.