Milchsäure-haltige cyclische Depsipeptide mit 18 Ringatomen als endoparasitizide Mittel und Verfahren zu ihrer Herstellung

Prodn. of lactic-acid-contg, optically active, cyclic depsipeptides with 18 ring atoms with the aid of a Fusarium fungus or an enzyme prepn. isolated from such a fungus is new. Also claimed is the prodn. of lactic-acid-contg. optically active, cyclic depsipeptides with 18 ring atoms (enniatins)of fo...

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Hauptverfasser:	ZOCHER, RAINER, PRIV. DOZ. DR., 12619 BERLIN, DE, JESCHKE, PETER., 51373 LEVERKUSEN, DE, HARDER, ACHIM.DR., 51109 KOELN, DE, MENCKE, NORBERT., 51381 LEVERKUSEN, DE, KLEINKAUF, HORST, DR., 12205 BERLIN, DE
Format:	Patent
Sprache:	ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS TRAPPING VINEGAR WINE
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Zusammenfassung:	Prodn. of lactic-acid-contg, optically active, cyclic depsipeptides with 18 ring atoms with the aid of a Fusarium fungus or an enzyme prepn. isolated from such a fungus is new. Also claimed is the prodn. of lactic-acid-contg. optically active, cyclic depsipeptides with 18 ring atoms (enniatins)of formula (I) from optically active amino acids of formula (II)-(IV), optically active or racemic alpha -hydroxy acids of formula (V) and (VI) and optically active or racemic lactic acid, where the reaction is effected in the presence of a Fusarium fungus in a nutrient medium or in the presence of a microbial synthetase in a buffer system: R1,R2 and R4 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, carboxyalkyl, alkoxycarbonylalkyl, carbamoylalkyl, aminoalkyl, alkylaminoalkyl, dialkylaminoalkyl, guanidinoalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2; R3 and R5 = H, 1-8C alkyl, hydroxyalkyl, mercaptoalkyl, alkylthioalkyl, alkylsulphinylalkyl, alkylsulphonylalkyl, 2-6C alkenyl, 3-8C cycloalkyl, or aralkyl or heteroarylalkyl opt. substd. by halogen, OH, alkoxy, alkyl, NO2 or NH2.