Proline and hydroxy:proline prodn. useful for carba:penem antibiotic prodn

Prodn. of aminoacids from proteins or peptides contg. proline (Pro) and/or hydroxyproline (Hypro) residues that are difficult to degrade is by using cells, pref. in an aq. medium, from Xanthomonas (X.) or its prod. which hydrolyses the protein or peptide. Pref., X. is X. maltophilia (malt.) or X. JC...

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Bibliographische Detailangaben
Hauptverfasser:	NIYOSHI, SHISUKE, FUNABASHI, CHIBA, KANAMORI, HIRONORI, FUNABASHI, CHIBA, SATO, NANAMI, FUNABASHI, CHIBA
Format:	Patent
Sprache:	eng ; ger
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HETEROCYCLIC COMPOUNDS METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Prodn. of aminoacids from proteins or peptides contg. proline (Pro) and/or hydroxyproline (Hypro) residues that are difficult to degrade is by using cells, pref. in an aq. medium, from Xanthomonas (X.) or its prod. which hydrolyses the protein or peptide. Pref., X. is X. maltophilia (malt.) or X. JCM 3857 (Ferm-BP-4475), X. malt NA-62 (FERM-BP-4479) or JCM 3807 (FERM-BP-4474). The proteins to be degraded are pref. collagen, casein or prolamine.Also claimed is method for prodn. of trans-4-hydroxy-L-proline by applying cells or a cell prod. of X. capable of hydrolysing the protein or peptide and isolating trans-4-hydroxy-L-proline.The ability to hydrolyse proteins or peptides that are difficult to degrade has the pref. meaning that all of benzyloxycarbonyl gp. (Z)-Pro-Pro, Z-Pro-hypro and Z-glycine-Pro can be hydrolysed.