BENZIMIDAZOLYLDERIVATE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZU IHRER HERSTELLUNG

The invention relates to benzimidazolyl derivatives of the general formula in which R1 is an amino group which is disubstituted by alkyl groups and in which one alkyl group can be substituted by a phenyl group, or is an optionally phenyl-, hydroxyl-, carboxyl-, alkylcarbonyl-, aminocarbonyl-, cyano-...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: MUELLER, THOMAS. DR., 7951 AEPFINGEN, DE, BINDER, KLAUS-BIOL. DR., 7951 WARTHAUSEN, DE, PSIORZ, MANFRED. DR., 6507 INGELHEIM, DE, HECKEL, ARMIN. DR., 7950 BIBERACH, DE, ZIMMERMANN, RAINER-BIO. DR., 7951 MITTELBIBERACH, DE, SAUTER, ROBERT. DR., 7958 LAUPHEIM, DE
Format: Patent
Sprache:ger
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to benzimidazolyl derivatives of the general formula in which R1 is an amino group which is disubstituted by alkyl groups and in which one alkyl group can be substituted by a phenyl group, or is an optionally phenyl-, hydroxyl-, carboxyl-, alkylcarbonyl-, aminocarbonyl-, cyano- or N-alkanoylalkylamino-substituted pyrrolidino, piperidino or hexamethyleneimino group, where the hydroxyl group cannot be in the position alpha to the ring nitrogen atom, one of the abovementioned piperidino groups can additionally be substituted by an alkyl group and, additionally, the methylene group in position 4 of the piperidino group can be replaced by an oxygen atom, a carbonyl, sulphinyl, imino or N-alkylimino group or an ethylene group in position 3,4 of the piperidino group or in position 4,5 of the hexamethyleneimino group can be replaced by an ethenylene, thiophenylene or thiazolylene group, or is a piperidino group which is substituted by two or three alkyl groups and in which the alkyl substituents can be identical or different, or is a tetrahydro-4H-thiazolo[4,5-d]azepin-6-yl or tetrahydrothiazolo[4',5':5,4]thieno[3,2-c]pyridin-7-yl group which is optionally substituted in position 2 by an amino group, R2 is a hydrogen atom or an alkyl group and R3 is a phenyl group which is optionally substituted by a fluorine, chlorine or bromine atom, by an alkyl, nitro, amino, alkylamino, dialkylamino, phenyl or cyclohexyl group, where the phenyl substituent can likewise be substituted by a fluorine, chlorine or bromine atom or by a nitro or amino group, or is a phenyl group which is substituted by fluorine, chlorine or bromine atoms or by alkyl or alkoxy groups, where one of the substituents can also be a nitro or amino group, or is a phenyl group which is substituted by a hydroxyl, amino, alkylamino, dialkylamino or pyrrolyl group, where the phenyl group is also substituted by two chlorine or bromine atoms or by two alkyl groups with 1 to 4 carbon atoms, and the pyrrolyl group can be substituted by one or two alkyl groups, or is a naphthyl group which is optionally mono- or disubstituted by hydroxyl, alkoxy or dialkylamino groups, or is an indanyl, quinolyl, 1,2,3,4-tetrahydroquinolyl, isoquinolyl, 1,2,3,4-tetrahydroisoquinolyl, carbazole, 1,2,3,4-tetrahydrocarbazole or dibenzofuranyl group which is optionally substituted by an alkyl group, where one imino group can additionally be substituted by an alkyl group which can also be substituted by a carboxyl