VERFAHREN ZUR HERSTELLUNG EINER PHARMAZEUTISCHEN ZUSAMMENSETZUNG, DIE PHARMAZEUTISCHE ZUSAMMENSETZUNG SOWIE DEREN VERWENDUNG

A pharmaceutical composition is prepared which takes the form of microparticles or of an implant comprising a biodegradable polymer chosen from poly(1,4-butylene succinate), poly(2,3-butylene succinate) and poly(1,4-butylene fumarate), incorporating as active substance a pamoate, tannate, stearate or palmitate of a natural or synthetic peptide comprising from 3 to 45 amino acids, such as LH-RH, somatostatin, GH-RH or calcitonin or one of their synthetic homologues or analogues. The preparation comprises dry mixing of the ingredients in pulverulent form, precompression and preheating of the mixture, followed by an extrusion of the precompressed and preheated mixture. The product resulting from the extrusion may then be pulverised and finally sieved.