BASISCHE SALZE DER 2-(2,6-DIEMTHYL-3,5-DIAETHOXYKARBOONYL-1,4-DIHYDROPYRIDIN-4-KARBOXAMIDO)AETHANSULFONSAEURE UND VERFAHREN ZUR HERSTELLUNG DERSELBEN

New compounds -alcaline salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido) ethane sulphonic acid have general formula (I), where Met = Na, Li. A method of obtaining said compounds provides for reacting pentafluoro-phenyl ether of 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-di...

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Hauptverfasser:	ULDRIKIS, JAN RICHARDOVIC, ELGAVA, SU, POIKANS, JANIS JAZEPOVIC, TIRZIT, GUNAR DZIMOVIC, RIGA, SU, BISENIEKS, EGILS ARVIDOVIC, RIGA, SU, GUREVIC, VIKTOR SAVEL'EVIC, MICHAILOVA, IRINA ARKADIEVNA, LENINGRAD, SU, DUBUR, GUNAR JANOVIC, RIGA, SU
Format:	Patent
Sprache:	ger
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	New compounds -alcaline salts of 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido) ethane sulphonic acid have general formula (I), where Met = Na, Li. A method of obtaining said compounds provides for reacting pentafluoro-phenyl ether of 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydroisonicotinic acid with taurine in the medium of an organic solvent in the presence of tertiary amine. As a result of reaction a mix is obtained containing the 2-(2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydropyridine-4-carboxamido) ethane sulphonic acid. The latter is extracted and subjected to reaction with hydrate of sodium oxide or lithium hydrate in the medium of a lower alcohol. The proposed compounds may be used in the medical field as antiaggregation means for treating cardiovascular diseases.