Novel nannocheline and methyl ester(s) - active against Gram positive microorganisms

Nannocheline and its Me esters of formula (I) and their nontoxic salts are new. (In (I), R and R' are each H or Me. Prepn. of cpds. (I) comprises propagation of nannocystis exedens (DSM 5530) in a suitable culture medium in the presence of an anion ion exchange resin; then sepn. of the resin, e...

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Hauptverfasser:	BEDORF, NORBERT, IRSCHIK, HERBERT, FORCHE, EDGAR, HOEFLE, GERHARD, DR, KUNZE, BRIGITTE, TROWITZSCH-KIENAST, WOLFRAM., 3300 BRAUNSCHWEIG, DE, REICHENBACH, HANS, DR, STEINMETZ, HEINRICH, JANSEN, ROLF, SASSE, FLORENZ, GERTH, KLAUS
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY SPIRITS VINEGAR WINE
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Zusammenfassung:	Nannocheline and its Me esters of formula (I) and their nontoxic salts are new. (In (I), R and R' are each H or Me. Prepn. of cpds. (I) comprises propagation of nannocystis exedens (DSM 5530) in a suitable culture medium in the presence of an anion ion exchange resin; then sepn. of the resin, elution with MeOH, and purification of the active fraction by chromatographic sepn. on sephadex and then silica gel. USE - (I) are new active against Gram positive microorganisms, but incompletely so against Escherichia coli and Saccharomyces cerevisiae.