ANTISENSE-OLIGONUKLEOTIDE ZUR INHIBIERUNG DER TRANSAKTIVATORZIELSEQUENZ (TAR) UND DER SYNTHESE DES TRANSAKTIVATORPROTEINS (TAT) AUS HIV-1 UND DEREN VERWENDUNG

The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have an...

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Hauptverfasser:	LOEBBERDING, ANTONIUS. DR, PIEL, NORBERT. DR., 4006 ERKRATH, DE, KRETSCHMER, AXEL. DR., 5060 BERGISCH GLADBACH, DE, FROMMER, WERNER, DR., 5600 WUPPERTAL, DE, KOELBL, HEINZ. DR., WEST HAVEN, CONN., US, BAUMGARTEN, JOERG, STROPP, UDO-BIO.. DR., 5657 HAAN, DE, SPRINGER, WOLFGANG-BIOL. DR., 5600 WUPPERTAL, DE
Format:	Patent
Sprache:	ger
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to chemically modified antisense oligonucleotides for inhibiting the transactivator target sequence (TAR) and the synthesis of the transactivator protein (tat) of HIV-1 and to the use thereof in pharmaceuticals. The chemically modified antisense oligonucleotides have antiviral effects. The pharmaceuticals can be used for the therapy of HIV infections. The antisense oligonucleotides are suitable as gene probes for detecting HIV.