6-Arylaminomethylchinolin-Derivate und ihre Verwendung als Antitumorwirkstoff

The invention relates to a quinoline of the formula:- wherein each of R and R , which may be the same or different, is hydrogen, halogeno, hydroxy, cyano, carbamoyl, nitro or amino, alkyl, alkoxy, alkylthio, alkylamino, dialkylamino or alkanoylamino each of up to 4 carbon atoms, or substituted alkyl or alkoxy each of up to 3 carbon atoms, provided that both R and R are not hydrogen; the quinoline ring may bear further substituents; R is hydrogen or alkyl of up to 4 carbon atoms; R is hydrogen, alkyl, alkenyl or alkynyl each of up to 4 carbon atoms or substituted alkyl of up to 3 carbon atoms; Ar is phenylene, naphthylene or heterocyclene which is unsubstituted or which bears one or more substituents; R is such that R -NH2 is an amino acid; or a pharmaceutically-acceptable salt or ester thereof. The compounds possess anti-tumour activity.