REKOMBINANT-ANTIKÖRPER

PCT No. PCT/GB88/00729 Sec. 371 Date Jul. 3, 1989 Sec. 102(e) Date Jul. 3, 1989 PCT Filed Sep. 5, 1988 PCT Pub. No. WO89/01782 PCT Pub. Date Mar. 9, 1989.The present invention provides an altered antibody molecule wherein a residue in a surface pocket on the molecule has been changed to a cysteine r...

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Hauptverfasser: ADAIR, JOHN, ROBERT, STOKENCHURCH HIGH WYCOMBE HP14 3RN, BODMER, MARK, WILLIAM, HENLEY-ON-THAMES OXFORDSHIRE R619 1DJ, WHITTLE, NIGEL, RICHARD, COBHAM SURREY KT11 2LF
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Zusammenfassung:PCT No. PCT/GB88/00729 Sec. 371 Date Jul. 3, 1989 Sec. 102(e) Date Jul. 3, 1989 PCT Filed Sep. 5, 1988 PCT Pub. No. WO89/01782 PCT Pub. Date Mar. 9, 1989.The present invention provides an altered antibody molecule wherein a residue in a surface pocket on the molecule has been changed to a cysteine residue to introduce a thiol group in the surface pocket and a process for its production by recombinant DNA technology.