N-ACYL-N-NAPHTHOYLGLYCINE ALS ALDOSE-REDUCTASE-INHIBITOREN

N-ACYL-N-NAPHTHOYLGLYCINE ALS ALDOSE-REDUCTASE-INHIBITOREN

Disclosed herein are N-acyl-N-naphthoylglycines, methods for their preparation and intermediates used therein. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications and have the formula: wherein R is fluorine, chlorine,...

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Bibliographische Detailangaben
Hauptverfasser: WROBEL, JAY E., LAWRENCEVILLE NEW JERSEY 08648, US, SESTANJ, KAZIMIR, MONMOUTH JUNCTION NEW JERSEY 08852, US
Format: Patent
Sprache:ger
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Disclosed herein are N-acyl-N-naphthoylglycines, methods for their preparation and intermediates used therein. The N-acyl-N-naphthoylglycines are novel aldose reductase inhibitors useful for the treatment or prevention of diabetic complications and have the formula: wherein R is fluorine, chlorine, bromine or trifluoroethoxy; R is lower alkyl containing 1 to 3 carbon atoms; X is -OH or -NH2 and the pharmaceutically acceptable salts thereof wherein X is -OH.