AROMATISCHE HETEROZYKLISCHE KARBONSAEUREAMIDABKOEMMLINGE, VERFAHREN ZUR HERSTELLUNG UND ARZNEIMITTEL, DIE DIESE ENTHALTEN

Heteroaryl carboxamides of formula (I) and their pharmaceutically acceptable salts are new: where A is 3-5C alkylene gp.; X is (i) or (ii) Het is a gp. of formula (II) or (III): Y is GH or N; R1 is OH, 1-6C alkoxy or mercapto; R2 is H, halogen, 1-6C alkoxy, 1-6C alkyl, nitro or cyano; R3 is 1-6C alk...

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Hauptverfasser: KON, TATSUYA, ASHIYA-SHI HYOGO 695, JP, SHINDO, TOKUHIKO, NARA-SHI NARA 630, JP, ISHII, KATSUMI, OTSU-SHI SHIGA 520, JP, UNO, HITOSHI, TAKATSUKI-SHI OSAKA 569, JP, NAKAMURA, HIDEO, TENRI-SHI NARA 632, JP, NISHIKAWA, YOSHINORI, IKEDA-SHI OSAKA 563, JP
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Sprache:ger
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Zusammenfassung:Heteroaryl carboxamides of formula (I) and their pharmaceutically acceptable salts are new: where A is 3-5C alkylene gp.; X is (i) or (ii) Het is a gp. of formula (II) or (III): Y is GH or N; R1 is OH, 1-6C alkoxy or mercapto; R2 is H, halogen, 1-6C alkoxy, 1-6C alkyl, nitro or cyano; R3 is 1-6C alkyl; when Y is N, then R2 is on the 7-position of the ring. Preferred are (I) where A is tetramethylene; Het is 7-(1-4C alkyl) 4-hydroxy-1,8- napthyridin-3-yl or 6-(1-4C alkyl) -2-hydroxy -3-pyridinyl or is 3-quinolinyl 4-substd. by OH, 1-4C alkoxy or SH and opt. substd. on the carbocyclic rib by OH, 1-4C alkyl, 1-4C alkoxy or CN. N-(4-(4-diphenyl methylene-1- piperidinyl) butyl)-4- hydroxy-7-methyl- 1,8napthyridine- 3-carboxamide.